Daughters May Inherit Ovarian Cancer Genes from Dads,Study Finds

US scientists have identified a new gene mutation which can raise the risk of ovarian cancer which is passed from father to daughter.The study found that genes on the X-chromosome get potentially transmitted through the father to his daughter and thereby increasing the risk of ovarian cancer in girls.A new study published in PLoS Genetics has shown that the genetic mutation inherited from the paternal grandmothers were also associated with higher rates of prostate cancer in fathers and sons as well.The researchers gathered information about pairs of granddaughters and grandmothers and arranged portions of the X-chromosome from 186 women who are affected by cancer. The results showed that a gene on the X-chromosome may contribute to a woman’s risk of developing ovarian cancer, independently of other known susceptibility genes, such as the BRCA genes.The American Cancer Society noted that less than 10 percent of ovarian cancers may be due to genetic mutations.Experts say more studies are essential to confirm the identity and function of the gene.Ovarian cancer is responsible for less than 2 percent of new cancer diagnoses in the United States each year.Almost half of the people with ovarian cancer are still alive five years after they are diagnosed.




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